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Dr. Bjordal suggests that we graded evidence for acetaminophen too positively. In his letter, Dr. Bjordal describes one trial as evaluating acute low back pain when it actually evaluated chronic low back pain (9). Otherwise, our descriptions of the evidence are similar (Appendix Tables 10 and 11 (2)). We agree that our evidence ratings for acetaminophen were generous given some inconsistency among trials of acute low back pain, and lack of direct evidence and small benefits for chronic low back pain. We re-rated evidence for acetaminophen for acute low back pain fair quality with moderate benefits, and for chronic low back pain fair quality with small benefits (see Correction). Because of acetaminophen's favorable safety profile compared to other pharmacologic therapies, these changes do not change our recommendation to consider it as a first-line option for pharmacologic therapy (1).
I have some breakthrough news for those of you constantly fighting the “battle of the tummy bulges!”
You’ve read how a sluggish thyroid can be responsible for weight gain. Getting your thyroid up to speed is crucial in any serious weight-management program.
However, there are areas on the body where it seems no matter how much we diet, watch what we eat, work out and take the proper supplements, the fat just refuses to budge.
The stomach and side obliques (love handles) are two such examples.
For whatever rhyme or reason, it looks like Mother Nature has taken some sort of wicked delight in making sure those “jelly-belly rolls” around our middle stay put.
I know this first-hand! Even after holding onto a nutritious diet, hitting the gym several times a week and leading a generally active, productive life, I still found it almost impossible to lose my love-handles. I definitely wasn’t the only person with this problem.
But here’s the good news … after months of research, I’ve come up with a unique, breakthrough supplement for directly targeting those stubborn, hard to displace abdominal fat reserves.
The secret lies with two little known bio-nutrients: