Testosterone and aging

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5α-Reductase inhibitors like finasteride and dutasteride can slightly increase circulating levels of testosterone by inhibiting its metabolism . [56] However, these drugs do this via prevention of the conversion of testosterone into its more potent metabolite dihydrotestosterone (DHT), and this results in dramatically reduced circulating levels of DHT (which circulates at much lower relative concentrations). [56] [57] In addition, local levels of DHT in so-called androgenic (5α-reductase-expressing) tissues are also markedly reduced, [56] [57] and this can have a strong impact on certain effects of testosterone. [58] [59] For instance, growth of body and facial hair and penile growth induced by testosterone may be inhibited by 5α-reductase inhibitors, and this could be considered undesirable in the context of, for instance, puberty induction . [59] [60] On the other hand, 5α-reductase inhibitors may prevent or reduce adverse androgenic side effects of testosterone like scalp hair loss , oily skin , acne , and seborrhea . [58] In addition to the prevention of testosterone conversion into DHT, 5α-reductase inhibitors also prevent the formation of neurosteroids like 3α-androstanediol from testosterone, and this may have neuropsychiatric consequences in some men. [61]

Additional information can be gained from measuring dihydrotestosterone (DHT) and estrogen; two substances to which testosterone can be metabolized. These can affect the amount of testosterone available and can cause unwanted side effects, such as breast enlargement, hair loss and prostate enlargement. A baseline PSA must be obtained to screen for preexisting prostate disease. Monitoring growth hormone, thyroid hormone, leutinizing hormone (LH), DHEA, lipid profile and blood count are also clinically prudent in a comprehensive hormone optimization program.

As men and women age their testosterone levels diminish. Testosterone is known as the Hormone of Desire . In middle-aged men, low testosterone symptoms (Low T) or Andropause start to appear. Some of the most profound symptoms of low testosterone are - feeling extremely tired all day, unexpected weight gain especially increased belly fat, loss of muscle or muscles getting flabby, low sex drive or a complete lack of desire, softer erections or complete erectile dysfunction, inability to sleep or outright insomnia, memory and hair loss, bursts of anger, social withdrawal and depression.

Testosterone and aging

testosterone and aging

As men and women age their testosterone levels diminish. Testosterone is known as the Hormone of Desire . In middle-aged men, low testosterone symptoms (Low T) or Andropause start to appear. Some of the most profound symptoms of low testosterone are - feeling extremely tired all day, unexpected weight gain especially increased belly fat, loss of muscle or muscles getting flabby, low sex drive or a complete lack of desire, softer erections or complete erectile dysfunction, inability to sleep or outright insomnia, memory and hair loss, bursts of anger, social withdrawal and depression.

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