Testosterone therapy has been in use for more than 70 years for the treatment of hypogonadism, also called testosterone deficiency. In the past 30 years there has been a growing body of scientific research demonstrating that testosterone deficiency is associated with increased body weight/adiposity/waist circumference, insulin resistance, type 2 diabetes, hypertension, inflammation, atherosclerosis and cardiovascular disease, erectile dysfunction (ED) and increased risk of mortality. In line with the detrimental health outcomes seen with testosterone deficiency, testosterone therapy has been shown to confer beneficial effects on multiple risk factors and risk biomarkers related to these clinical conditions.
The thing is that fenugreek extracts haven’t always performed this well on scientific studies. Although in rodents, the extract increased muscle growth, it failed to have any impact on circulating testosterone levels 5 . In an effort to replicate the first human study sponsored by Indus Biotech, Bushey et al. found that in their trial, fenugreek did not increase either free or total testosterone levels, but it ended up lowering DHT due to 5-a reductase inhibitory effect 6 . Lastly, a study using 600mg/day of fenugreek extract called “Testofen” on healthy male subjects, failed to show any increases in testosterone levels 7 .