The assumed reductions in DHT resulting from TREN treatment and its subsequent suppression of endogenous testosterone release may translate into the maintenance of normal cardiac structure and function in the presence of the exogenous androgen. No adverse changes were observed in cardiovascular structure or function in response to TREN treatment in the current study (Table 3). Androgen receptors, present in cardiac myocytes of multiple species, including humans, mediate a hypertrophic response in the myocardium . Despite TREN treatment’s suppression of endogenous testosterone release, we did not observe reductions in heart weight or function which appears to be preserved by the TREN treatment.
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Testosterone can be administered parenterally , but it has more irregular prolonged absorption time and greater activity in muscle in enanthate , undecanoate , or cypionate ester form. These derivatives are hydrolyzed to release free testosterone at the site of injection; absorption rate (and thus injection schedule) varies among different esters, but medical injections are normally done anywhere between semi-weekly to once every 12 weeks. A more frequent schedule may be desirable in order to maintain a more constant level of hormone in the system.  Injectable steroids are typically administered into the muscle, not into the vein, to avoid sudden changes in the amount of the drug in the bloodstream. In addition, because estered testosterone is dissolved in oil, intravenous injection has the potential to cause a dangerous embolism (clot) in the bloodstream.