Tell your doctor if you are or plan to become pregnant, are breastfeeding or plan to breastfeed. INVOKAMET® may harm your unborn baby. If you become pregnant while taking INVOKAMET®, tell your doctor as soon as possible. If you are a premenopausal woman (before the "change of life"), who does not have periods regularly or at all, INVOKAMET® may increase your chance of becoming pregnant. Talk to your doctor about birth control choices while taking INVOKAMET®, if not planning to become pregnant. Tell your doctor right away if you become pregnant. INVOKAMET® may pass into your breast milk and harm your baby. Do not breastfeed while taking INVOKAMET®.
CNS depression potentiated with alcohol, other CNS depressants. Possible neurotoxicity with lithium: monitor, discontinue if occurs. Caution with drugs that prolong the QT interval (eg, ketoconazole, paroxetine). May be potentiated by CYP3A4 or CYP2D6 inhibitors/substrates (eg, itraconazole, nefazodone, buspirone, venlafaxine, alprazolam, fluvoxamine, quinidine, fluoxetine, sertraline, chlorpromazine, promethazine. May be antagonized by CYP3A4 inducers (eg, rifampin, carbamazepine); monitor and adjust doses. May increase intraocular pressure with anticholinergics, antiparkinson agents. Monitor anticoagulants.