ONC1-0013B inhibits AR activity in vitro. A. ONC1-0013B structure. B. LnCAP cells cultured (10% CSS) for 3 days, then treated with tested compounds in presence of 1nM DHT for 1 day. PSA expression plotted as percentage of vehicle control (DMSO; n=2, mean±SEM). Ki values: ± (ONC1-13B), ± (MDV3100), (ARN-509). Mean±SEM from 5 replicate experiments (except ARN-509). C. LnCAP cells cultured (10% CSS) for 3 days, then treated with tested compounds in presence of 1nM DHT for 5 days. Viable cells plotted as percentage of vehicle control (DMSO; n=2, mean±SEM). IC50 values: 30nM (ONC1-13B), 148nM (MDV3100), 240nM (ARN-509). D. Competitive-binding assay vs AR ligand Fluormone™ (PolarScreen™ Androgen Receptor Competitor Assay). IC50 values: 19nM (DHT), (ONC1-13B), (MDV3100).
1-Testosterone Cypionate (Dihydroboldenone)(DHB)
Raw Trenbolone Base
Trenbolone Hexahydrobenzylcarbonate (Parabolan)
Boldenone Acetate (Equipoise Acetate)
Drostanolone Enanthate(Masteron Enanthate)
Drostanolone Propionate(Masteron Propionate)
Nandrolone Decanoate(Deca Durabolin)
Metenolone Enanthate(Primobolan Depot)
Metenolone Acetate (Methenolone Acetate)(Primobolan)
Clomifene Citrate (Clomid)
Mibolerone(Cheque Drops, Matenon)
Andarine S4 Powder
SR 9009(Stenabolic) Powder
The Story: In February 2005 Canseco released his autobiography and steroid tell-all, Juiced , Wild Times, Rampant 'Roids, Smash Hits, and How Baseball Got Big. In it he described himself as 'the chemist' having experimented on himself for years. He claimed to have educated and personally injected many players including Mark McGwire, Rafael Palmeiro, Juan Gonzalez, Ivan Rodriguez, and Jason Giambi. In his second book, Vindicated , Canseco added Magglio Ordonez to the list of players he had educated and injected with steroids. He also said he introduced Alex Rodriguez to a trainer/PED supplier after Rodriguez had asked where he could get steroids.